Endocrine Abstracts

Type 1 deiodinase (D1) catalyses deiodination of tyroxine (T4), which leads either to synthesis of triiodothyronine or reverse triiodothyronine (rT3). T3 can influence the process of neoplasia through its receptors which act as transcription factors and regulate the expression of many tumor suppressor genes and oncogenes. The aim of the study was to analyze the changes in expression of alternatively spliced variants of D1 mRNA in clear cell Renal Cell Carcinoma (ccRCC), which ...

Introduction: Type 1 iodothyronine deiodinase (DIO1) is one of the three enzymes regulating bioavailability of thyroid hormones. In contrast to DIO2 and DIO3, the specific cellular role of DIO1 remains controversial. Our previous studies showed that DIO1 expression in clear cell renal cell carcinoma (ccRCC) is decreased, followed by lowered intracellular T3 concentration. In this study we explored how re-introduction of DIO1 in ccRCC cells affects their mig...